Screening of Secondary Metabolites and Semi-Synthetic Analogues of Ramalina leiodea (Nyl.) Nyl. against Free Radicals Inflammation and Cancer Cell Lines

The objective of the present study is to evaluate pharmacological actions earlier reported metabolites (1-5), and semi-synthetic analogs (4a-e) from acetone extract Ramalina leiodea. Acetone leiodea were screened for antioxidant, anti-inflammatory, anticancer, acute toxicity studies. antioxidant results exhibited that compound 4e showed effective inhibitory ability against ferric ions, 2,2-diphenyl-1-picrylhydrazyl superoxide free radicals with 50 % inhibition value 28.50, 27.0, 25.0 μg/ml, respectively. Also, among all samples, revealed good albumin denaturation 105 μg/ml (IC50 value). Additionally, median lethal dosage was observed be above 2000 mg/Kg body weight. in vivo antiinflammatory studies a noticeable reduction edema rat paw at both low high when compared indomethacin. From sulforhodamine B assay, it concluded 2 4b displayed noteworthy degree specificity tested series cell lines. On other hand, samples normal cells. To conclude, could best source bioactive agents management oxidative stress, inflammation, cancer.